diff --git a/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegion.java b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegion.java
index c5ba10977a7..5cbc4da652c 100644
--- a/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegion.java
+++ b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegion.java
@@ -144,6 +144,7 @@ import org.apache.hadoop.hbase.regionserver.ScannerContext.LimitScope;
 import org.apache.hadoop.hbase.regionserver.ScannerContext.NextState;
 import org.apache.hadoop.hbase.regionserver.compactions.CompactionContext;
 import org.apache.hadoop.hbase.regionserver.compactions.CompactionLifeCycleTracker;
+import org.apache.hadoop.hbase.regionserver.compactions.ForbidMajorCompactionChecker;
 import org.apache.hadoop.hbase.regionserver.throttle.CompactionThroughputControllerFactory;
 import org.apache.hadoop.hbase.regionserver.throttle.NoLimitThroughputController;
 import org.apache.hadoop.hbase.regionserver.throttle.StoreHotnessProtector;
@@ -1992,6 +1993,14 @@ public class HRegion implements HeapSize, PropagatingConfigurationObserver, Regi
     return compact(compaction, store, throughputController, null);
   }
 
+  private boolean shouldForbidMajorCompaction() {
+    if (rsServices != null && rsServices.getReplicationSourceService() != null) {
+      return rsServices.getReplicationSourceService().getSyncReplicationPeerInfoProvider()
+          .checkState(getRegionInfo(), ForbidMajorCompactionChecker.get());
+    }
+    return false;
+  }
+
   public boolean compact(CompactionContext compaction, HStore store,
       ThroughputController throughputController, User user) throws IOException {
     assert compaction != null && compaction.hasSelection();
@@ -2001,6 +2010,15 @@ public class HRegion implements HeapSize, PropagatingConfigurationObserver, Regi
       store.cancelRequestedCompaction(compaction);
       return false;
     }
+
+    if (compaction.getRequest().isAllFiles() && shouldForbidMajorCompaction()) {
+      LOG.warn("Skipping major compaction on " + this
+          + " because this cluster is transiting sync replication state"
+          + " from STANDBY to DOWNGRADE_ACTIVE");
+      store.cancelRequestedCompaction(compaction);
+      return false;
+    }
+
     MonitoredTask status = null;
     boolean requestNeedsCancellation = true;
     /*
diff --git a/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegionServer.java b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegionServer.java
index e49fd6121eb..677ee05e9ca 100644
--- a/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegionServer.java
+++ b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/HRegionServer.java
@@ -2475,7 +2475,7 @@ public class HRegionServer extends HasThread implements
    * @return Return the object that implements the replication
    * source executorService.
    */
-  @VisibleForTesting
+  @Override
   public ReplicationSourceService getReplicationSourceService() {
     return replicationSourceHandler;
   }
diff --git a/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/RegionServerServices.java b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/RegionServerServices.java
index 00f4077731f..7c4362c68fb 100644
--- a/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/RegionServerServices.java
+++ b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/RegionServerServices.java
@@ -262,4 +262,9 @@ public interface RegionServerServices extends Server, MutableOnlineRegions, Favo
    * @return True if cluster is up; false if cluster is not up (we are shutting down).
    */
   boolean isClusterUp();
+
+  /**
+   * @return Return the object that implements the replication source executorService.
+   */
+  ReplicationSourceService getReplicationSourceService();
 }
diff --git a/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/compactions/ForbidMajorCompactionChecker.java b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/compactions/ForbidMajorCompactionChecker.java
new file mode 100644
index 00000000000..eecc7805712
--- /dev/null
+++ b/hbase-server/src/main/java/org/apache/hadoop/hbase/regionserver/compactions/ForbidMajorCompactionChecker.java
@@ -0,0 +1,44 @@
+/**
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+package org.apache.hadoop.hbase.regionserver.compactions;
+
+import java.util.function.BiPredicate;
+
+import org.apache.hadoop.hbase.replication.SyncReplicationState;
+import org.apache.yetus.audience.InterfaceAudience;
+
+/**
+ * Check whether forbid major compaction for region.
+ */
+@InterfaceAudience.Private
+public class ForbidMajorCompactionChecker
+    implements BiPredicate<SyncReplicationState, SyncReplicationState> {
+
+  private static final ForbidMajorCompactionChecker INST = new ForbidMajorCompactionChecker();
+
+  @Override
+  public boolean test(SyncReplicationState state, SyncReplicationState newState) {
+    // Forbid major compaction when cluster transit sync replication state from S to DA
+    return state == SyncReplicationState.STANDBY
+        || newState == SyncReplicationState.DOWNGRADE_ACTIVE;
+  }
+
+  public static ForbidMajorCompactionChecker get() {
+    return INST;
+  }
+}
diff --git a/hbase-server/src/test/java/org/apache/hadoop/hbase/MockRegionServerServices.java b/hbase-server/src/test/java/org/apache/hadoop/hbase/MockRegionServerServices.java
index b6202fd094d..a550bf56cd1 100644
--- a/hbase-server/src/test/java/org/apache/hadoop/hbase/MockRegionServerServices.java
+++ b/hbase-server/src/test/java/org/apache/hadoop/hbase/MockRegionServerServices.java
@@ -48,6 +48,7 @@ import org.apache.hadoop.hbase.regionserver.MetricsRegionServer;
 import org.apache.hadoop.hbase.regionserver.Region;
 import org.apache.hadoop.hbase.regionserver.RegionServerAccounting;
 import org.apache.hadoop.hbase.regionserver.RegionServerServices;
+import org.apache.hadoop.hbase.regionserver.ReplicationSourceService;
 import org.apache.hadoop.hbase.regionserver.SecureBulkLoadManager;
 import org.apache.hadoop.hbase.regionserver.ServerNonceManager;
 import org.apache.hadoop.hbase.regionserver.compactions.CompactionRequester;
@@ -353,4 +354,9 @@ public class MockRegionServerServices implements RegionServerServices {
   public boolean isClusterUp() {
     return true;
   }
+
+  @Override
+  public ReplicationSourceService getReplicationSourceService() {
+    return null;
+  }
 }
diff --git a/hbase-server/src/test/java/org/apache/hadoop/hbase/master/MockRegionServer.java b/hbase-server/src/test/java/org/apache/hadoop/hbase/master/MockRegionServer.java
index 35ad7ebd431..1c4e72afdf3 100644
--- a/hbase-server/src/test/java/org/apache/hadoop/hbase/master/MockRegionServer.java
+++ b/hbase-server/src/test/java/org/apache/hadoop/hbase/master/MockRegionServer.java
@@ -61,6 +61,7 @@ import org.apache.hadoop.hbase.regionserver.MetricsRegionServer;
 import org.apache.hadoop.hbase.regionserver.Region;
 import org.apache.hadoop.hbase.regionserver.RegionServerAccounting;
 import org.apache.hadoop.hbase.regionserver.RegionServerServices;
+import org.apache.hadoop.hbase.regionserver.ReplicationSourceService;
 import org.apache.hadoop.hbase.regionserver.SecureBulkLoadManager;
 import org.apache.hadoop.hbase.regionserver.ServerNonceManager;
 import org.apache.hadoop.hbase.regionserver.compactions.CompactionRequester;
@@ -696,4 +697,9 @@ ClientProtos.ClientService.BlockingInterface, RegionServerServices {
   public boolean isClusterUp() {
     return true;
   }
+
+  @Override
+  public ReplicationSourceService getReplicationSourceService() {
+    return null;
+  }
 }