diff --git a/jetty-client/src/main/java/org/eclipse/jetty/client/HttpClient.java b/jetty-client/src/main/java/org/eclipse/jetty/client/HttpClient.java
index fb068333dff..3b6da5bee48 100644
--- a/jetty-client/src/main/java/org/eclipse/jetty/client/HttpClient.java
+++ b/jetty-client/src/main/java/org/eclipse/jetty/client/HttpClient.java
@@ -528,7 +528,8 @@ public class HttpClient extends ContainerLifeCycle
         if (!HttpScheme.HTTP.is(scheme) && !HttpScheme.HTTPS.is(scheme))
             throw new IllegalArgumentException("Invalid protocol " + scheme);
 
-        HttpDestination destination = destinationFor(scheme, request.getHost(), request.getPort());
+        String host = request.getHost().toLowerCase(Locale.ENGLISH);
+        HttpDestination destination = destinationFor(scheme, host, request.getPort());
         destination.send(request, listeners);
     }
 
diff --git a/jetty-client/src/main/java/org/eclipse/jetty/client/HttpDestination.java b/jetty-client/src/main/java/org/eclipse/jetty/client/HttpDestination.java
index aca7c85a540..2d7a55ba9e3 100644
--- a/jetty-client/src/main/java/org/eclipse/jetty/client/HttpDestination.java
+++ b/jetty-client/src/main/java/org/eclipse/jetty/client/HttpDestination.java
@@ -161,9 +161,9 @@ public abstract class HttpDestination implements Destination, Closeable, Dumpabl
 
     protected void send(HttpRequest request, List<Response.ResponseListener> listeners)
     {
-        if (!getScheme().equals(request.getScheme()))
+        if (!getScheme().equalsIgnoreCase(request.getScheme()))
             throw new IllegalArgumentException("Invalid request scheme " + request.getScheme() + " for destination " + this);
-        if (!getHost().equals(request.getHost()))
+        if (!getHost().equalsIgnoreCase(request.getHost()))
             throw new IllegalArgumentException("Invalid request host " + request.getHost() + " for destination " + this);
         int port = request.getPort();
         if (port >= 0 && getPort() != port)
diff --git a/jetty-client/src/test/java/org/eclipse/jetty/client/HttpClientURITest.java b/jetty-client/src/test/java/org/eclipse/jetty/client/HttpClientURITest.java
index 8b565ce4d31..d6eb4e9baaf 100644
--- a/jetty-client/src/test/java/org/eclipse/jetty/client/HttpClientURITest.java
+++ b/jetty-client/src/test/java/org/eclipse/jetty/client/HttpClientURITest.java
@@ -432,4 +432,43 @@ public class HttpClientURITest extends AbstractHttpClientServerTest
         Assert.assertEquals(HttpStatus.OK_200, response.getStatus());
     }
 
+    @Test
+    public void testSchemeIsCaseInsensitive() throws Exception
+    {
+        start(new AbstractHandler()
+        {
+            @Override
+            public void handle(String target, org.eclipse.jetty.server.Request baseRequest, HttpServletRequest request, HttpServletResponse response) throws IOException, ServletException
+            {
+                baseRequest.setHandled(true);
+            }
+        });
+
+        ContentResponse response = client.newRequest("localhost", connector.getLocalPort())
+                .scheme(scheme.toUpperCase())
+                .timeout(5, TimeUnit.SECONDS)
+                .send();
+
+        Assert.assertEquals(HttpStatus.OK_200, response.getStatus());
+    }
+
+    @Test
+    public void testHostIsCaseInsensitive() throws Exception
+    {
+        start(new AbstractHandler()
+        {
+            @Override
+            public void handle(String target, org.eclipse.jetty.server.Request baseRequest, HttpServletRequest request, HttpServletResponse response) throws IOException, ServletException
+            {
+                baseRequest.setHandled(true);
+            }
+        });
+
+        ContentResponse response = client.newRequest("LOCALHOST", connector.getLocalPort())
+                .scheme(scheme)
+                .timeout(5, TimeUnit.SECONDS)
+                .send();
+
+        Assert.assertEquals(HttpStatus.OK_200, response.getStatus());
+    }
 }