diff --git a/wp-includes/class-wp-editor.php b/wp-includes/class-wp-editor.php
index 7ce043a896..b9ba53be9a 100644
--- a/wp-includes/class-wp-editor.php
+++ b/wp-includes/class-wp-editor.php
@@ -1411,8 +1411,16 @@ final class _WP_Editors {
 		$version = 'ver=' . $tinymce_version;
 		$baseurl = self::get_baseurl();
 
+		$has_custom_theme = false;
+		foreach ( self::$mce_settings as $init ) {
+			if ( ! empty( $init['theme_url'] ) ) {
+				$has_custom_theme = true;
+				break;
+			}
+		}
+
 		$compressed = $compress_scripts && $concatenate_scripts && isset( $_SERVER['HTTP_ACCEPT_ENCODING'] )
-			&& false !== stripos( $_SERVER['HTTP_ACCEPT_ENCODING'], 'gzip' );
+			&& false !== stripos( $_SERVER['HTTP_ACCEPT_ENCODING'], 'gzip' ) && ! $has_custom_theme;
 
 		// Load tinymce.js when running from /src, else load wp-tinymce.js.gz (production) or tinymce.min.js (SCRIPT_DEBUG)
 		$mce_suffix = false !== strpos( get_bloginfo( 'version' ), '-src' ) ? '' : '.min';
diff --git a/wp-includes/version.php b/wp-includes/version.php
index a22b2850b1..51d2feee83 100644
--- a/wp-includes/version.php
+++ b/wp-includes/version.php
@@ -4,7 +4,7 @@
  *
  * @global string $wp_version
  */
-$wp_version = '5.0-alpha-43220';
+$wp_version = '5.0-alpha-43222';
 
 /**
  * Holds the WordPress DB revision, increments when changes are made to the WordPress DB schema.