diff --git a/wp-admin/includes/upgrade.php b/wp-admin/includes/upgrade.php
index f8b871db49..82a6530e2c 100644
--- a/wp-admin/includes/upgrade.php
+++ b/wp-admin/includes/upgrade.php
@@ -793,6 +793,10 @@ function upgrade_all() {
 		upgrade_460();
 	}
 
+	if ( $wp_current_db_version < 43764 ) {
+		upgrade_500();
+	}
+
 	maybe_disable_link_manager();
 
 	maybe_disable_automattic_widgets();
@@ -2069,6 +2073,25 @@ function upgrade_460() {
 	}
 }
 
+/**
+ * Executes changes made in WordPress 5.0.0.
+ *
+ * @ignore
+ * @since 5.0.0
+ *
+ * @global int $wp_current_db_version Current database version.
+ */
+function upgrade_500() {
+	global $wp_current_db_version;
+	if ( $wp_current_db_version < 43764 ) {
+		// Allow bypassing Gutenberg plugin deactivation.
+		if ( defined( 'GUTENBERG_USE_PLUGIN' ) && GUTENBERG_USE_PLUGIN ) {
+			return;
+		}
+		deactivate_plugins( array( 'gutenberg/gutenberg.php' ), true );
+	}
+}
+
 /**
  * Executes network-level upgrade routines.
  *
diff --git a/wp-includes/version.php b/wp-includes/version.php
index 2b6f1a912f..cc17b085b3 100644
--- a/wp-includes/version.php
+++ b/wp-includes/version.php
@@ -13,14 +13,14 @@
  *
  * @global string $wp_version
  */
-$wp_version = '5.1-alpha-44124';
+$wp_version = '5.1-alpha-44125';
 
 /**
  * Holds the WordPress DB revision, increments when changes are made to the WordPress DB schema.
  *
  * @global int $wp_db_version
  */
-$wp_db_version = 42836;
+$wp_db_version = 43764;
 
 /**
  * Holds the TinyMCE version