diff --git a/packages/core/src/di/interface/defs.ts b/packages/core/src/di/interface/defs.ts
index 7a6662371b..01e5261da4 100644
--- a/packages/core/src/di/interface/defs.ts
+++ b/packages/core/src/di/interface/defs.ts
@@ -218,7 +218,10 @@ function getOwnDefinition<T>(type: any, def: ɵɵInjectableDef<T>): ɵɵInjectab
  * `ɵprov` on an ancestor only.
  */
 export function getInheritedInjectableDef<T>(type: any): ɵɵInjectableDef<T>|null {
-  const def = type && (type[NG_PROV_DEF] || type[NG_INJECTABLE_DEF]);
+  // See `jit/injectable.ts#compileInjectable` for context on NG_PROV_DEF_FALLBACK.
+  const def = type && (type[NG_PROV_DEF] || type[NG_INJECTABLE_DEF] ||
+                       (type[NG_PROV_DEF_FALLBACK] && type[NG_PROV_DEF_FALLBACK]()));
+
   if (def) {
     // TODO(FW-1307): Re-add ngDevMode when closure can handle it
     // ngDevMode &&
@@ -245,6 +248,14 @@ export function getInjectorDef<T>(type: any): ɵɵInjectorDef<T>|null {
 export const NG_PROV_DEF = getClosureSafeProperty({ɵprov: getClosureSafeProperty});
 export const NG_INJ_DEF = getClosureSafeProperty({ɵinj: getClosureSafeProperty});
 
+// On IE10 properties defined via `defineProperty` won't be inherited by child classes,
+// which will break inheriting the injectable definition from a grandparent through an
+// undecorated parent class. We work around it by defining a fallback method which will be
+// used to retrieve the definition. This should only be a problem in JIT mode, because in
+// AOT TypeScript seems to have a workaround for static properties. When inheriting from an
+// undecorated parent is no longer supported in v10, this can safely be removed.
+export const NG_PROV_DEF_FALLBACK = getClosureSafeProperty({ɵprovFallback: getClosureSafeProperty});
+
 // We need to keep these around so we can read off old defs if new defs are unavailable
 export const NG_INJECTABLE_DEF = getClosureSafeProperty({ngInjectableDef: getClosureSafeProperty});
 export const NG_INJECTOR_DEF = getClosureSafeProperty({ngInjectorDef: getClosureSafeProperty});
diff --git a/packages/core/src/di/jit/injectable.ts b/packages/core/src/di/jit/injectable.ts
index c01ad1b121..ee18d1a577 100644
--- a/packages/core/src/di/jit/injectable.ts
+++ b/packages/core/src/di/jit/injectable.ts
@@ -12,7 +12,7 @@ import {NG_FACTORY_DEF} from '../../render3/fields';
 import {getClosureSafeProperty} from '../../util/property';
 import {resolveForwardRef} from '../forward_ref';
 import {Injectable} from '../injectable';
-import {NG_PROV_DEF} from '../interface/defs';
+import {NG_PROV_DEF, NG_PROV_DEF_FALLBACK} from '../interface/defs';
 import {ClassSansProvider, ExistingSansProvider, FactorySansProvider, ValueProvider, ValueSansProvider} from '../interface/provider';
 
 import {angularCoreDiEnv} from './environment';
@@ -40,6 +40,16 @@ export function compileInjectable(type: Type<any>, srcMeta?: Injectable): void {
         return ngInjectableDef;
       },
     });
+
+    // On IE10 properties defined via `defineProperty` won't be inherited by child classes,
+    // which will break inheriting the injectable definition from a grandparent through an
+    // undecorated parent class. We work around it by defining a method which should be used
+    // as a fallback. This should only be a problem in JIT mode, because in AOT TypeScript
+    // seems to have a workaround for static properties. When inheriting from an undecorated
+    // parent is no longer supported in v10, this can safely be removed.
+    if (!type.hasOwnProperty(NG_PROV_DEF_FALLBACK)) {
+      (type as any)[NG_PROV_DEF_FALLBACK] = () => (type as any)[NG_PROV_DEF];
+    }
   }
 
   // if NG_FACTORY_DEF is already defined on this class then don't overwrite it
diff --git a/packages/core/test/bundling/injection/bundle.golden_symbols.json b/packages/core/test/bundling/injection/bundle.golden_symbols.json
index 76e6fcdb57..b8cef691a6 100644
--- a/packages/core/test/bundling/injection/bundle.golden_symbols.json
+++ b/packages/core/test/bundling/injection/bundle.golden_symbols.json
@@ -38,6 +38,9 @@
   {
     "name": "NG_PROV_DEF"
   },
+  {
+    "name": "NG_PROV_DEF_FALLBACK"
+  },
   {
     "name": "NG_TEMP_TOKEN_PATH"
   },