diff --git a/packages/router/src/operators/activate_routes.ts b/packages/router/src/operators/activate_routes.ts
index 094da9649c..8abe7300f1 100644
--- a/packages/router/src/operators/activate_routes.ts
+++ b/packages/router/src/operators/activate_routes.ts
@@ -123,6 +123,11 @@ export class ActivateRoutes {
       context.outlet.deactivate();
       // Destroy the contexts for all the outlets that were in the component
       context.children.onOutletDeactivated();
+      // Clear the information about the attached component on the context but keep the reference to
+      // the outlet.
+      context.attachRef = null;
+      context.resolver = null;
+      context.route = null;
     }
   }
 
diff --git a/packages/router/test/regression_integration.spec.ts b/packages/router/test/regression_integration.spec.ts
index 9dd5b8ba32..84b5117c5e 100644
--- a/packages/router/test/regression_integration.spec.ts
+++ b/packages/router/test/regression_integration.spec.ts
@@ -7,7 +7,7 @@
  */
 
 import {CommonModule} from '@angular/common';
-import {ChangeDetectionStrategy, Component, ContentChild, NgModule, TemplateRef, Type, ViewChild, ViewContainerRef} from '@angular/core';
+import {ChangeDetectionStrategy, ChangeDetectorRef, Component, NgModule, TemplateRef, Type, ViewChild, ViewContainerRef} from '@angular/core';
 import {ComponentFixture, fakeAsync, TestBed, tick} from '@angular/core/testing';
 import {Router} from '@angular/router';
 import {RouterTestingModule} from '@angular/router/testing';
@@ -187,6 +187,46 @@ describe('Integration', () => {
          expect(fixture.nativeElement.innerHTML).toContain('isActive: true');
        }));
   });
+
+  it('should not reactivate a deactivated outlet when destroyed and recreated - #41379',
+     fakeAsync(() => {
+       @Component({template: 'simple'})
+       class SimpleComponent {
+       }
+
+       @Component({template: ` <router-outlet *ngIf="outletVisible" name="aux"></router-outlet> `})
+       class AppComponent {
+         outletVisible = true;
+       }
+
+       TestBed.configureTestingModule({
+         imports: [RouterTestingModule.withRoutes(
+             [{path: ':id', component: SimpleComponent, outlet: 'aux'}])],
+         declarations: [SimpleComponent, AppComponent],
+       });
+
+       const router = TestBed.inject(Router);
+       const fixture = createRoot(router, AppComponent);
+       const componentCdr = fixture.componentRef.injector.get<ChangeDetectorRef>(ChangeDetectorRef);
+
+       router.navigate([{outlets: {aux: ['1234']}}]);
+       advance(fixture);
+       expect(fixture.nativeElement.innerHTML).toContain('simple');
+
+       router.navigate([{outlets: {aux: null}}]);
+       advance(fixture);
+       expect(fixture.nativeElement.innerHTML).not.toContain('simple');
+
+       fixture.componentInstance.outletVisible = false;
+       componentCdr.detectChanges();
+       expect(fixture.nativeElement.innerHTML).not.toContain('simple');
+       expect(fixture.nativeElement.innerHTML).not.toContain('router-outlet');
+
+       fixture.componentInstance.outletVisible = true;
+       componentCdr.detectChanges();
+       expect(fixture.nativeElement.innerHTML).toContain('router-outlet');
+       expect(fixture.nativeElement.innerHTML).not.toContain('simple');
+     }));
 });
 
 function advance<T>(fixture: ComponentFixture<T>): void {