diff --git a/integration/hello_world__closure/package.json b/integration/hello_world__closure/package.json
index f09cc3583c..e79b18dabd 100644
--- a/integration/hello_world__closure/package.json
+++ b/integration/hello_world__closure/package.json
@@ -13,7 +13,7 @@
     "google-closure-compiler": "^20161201.0.0",
     "rxjs": "file:../../node_modules/rxjs",
     "source-map-explorer": "^1.3.3",
-    "typescript": "~2.0",
+    "typescript": "~2.1",
     "zone.js": "^0.7.6"
   },
   "devDependencies": {
diff --git a/integration/rxjs.tsconfig.json b/integration/rxjs.tsconfig.json
index 775fb36b48..5c8124d186 100644
--- a/integration/rxjs.tsconfig.json
+++ b/integration/rxjs.tsconfig.json
@@ -5,12 +5,13 @@
     "annotateForClosureCompiler": true
   },
 
-  /**
-   * Remaining options are copied from
-   * https://github.com/ReactiveX/rxjs/blob/cba74135810a8e6bbe0b3c7732e8544b0869589e/tsconfig.json
-   * TODO(alexeagle): use "extends" instead when Angular is on TS 2.1
-   */
   "compilerOptions": {
+    "types": [],
+    /**
+      * Remaining options are copied from
+      * https://github.com/ReactiveX/rxjs/blob/cba74135810a8e6bbe0b3c7732e8544b0869589e/tsconfig.json
+      * TODO(alexeagle): use "extends" instead when Angular is on TS 2.1
+      */
     "removeComments": false,
     "preserveConstEnums": true,
     "sourceMap": true,
diff --git a/integration/typings_test_ts20/include-all.ts b/integration/typings_test_ts21/include-all.ts
similarity index 100%
rename from integration/typings_test_ts20/include-all.ts
rename to integration/typings_test_ts21/include-all.ts
diff --git a/integration/typings_test_ts20/package.json b/integration/typings_test_ts21/package.json
similarity index 97%
rename from integration/typings_test_ts20/package.json
rename to integration/typings_test_ts21/package.json
index 52fa28cd24..cc9b76a83b 100644
--- a/integration/typings_test_ts20/package.json
+++ b/integration/typings_test_ts21/package.json
@@ -18,7 +18,7 @@
     "@types/jasmine": "^2.5.41",
     "rxjs": "file:../../node_modules/rxjs",
     "source-map-explorer": "^1.3.3",
-    "typescript": "~2.0",
+    "typescript": "~2.1",
     "zone.js": "^0.7.6"
   },
   "scripts": {
diff --git a/integration/typings_test_ts20/tsconfig.json b/integration/typings_test_ts21/tsconfig.json
similarity index 100%
rename from integration/typings_test_ts20/tsconfig.json
rename to integration/typings_test_ts21/tsconfig.json
diff --git a/modules/@angular/benchpress/src/webdriver/chrome_driver_extension.ts b/modules/@angular/benchpress/src/webdriver/chrome_driver_extension.ts
index aa7cd0c955..6109ed5b87 100644
--- a/modules/@angular/benchpress/src/webdriver/chrome_driver_extension.ts
+++ b/modules/@angular/benchpress/src/webdriver/chrome_driver_extension.ts
@@ -68,7 +68,7 @@ export class ChromeDriverExtension extends WebDriverExtension {
         .then((_) => this._driver.logs('performance'))
         .then((entries) => {
           const events: PerfLogEvent[] = [];
-          entries.forEach(entry => {
+          entries.forEach((entry: any) => {
             const message = JSON.parse(entry['message'])['message'];
             if (message['method'] === 'Tracing.dataCollected') {
               events.push(message['params']);
diff --git a/modules/@angular/benchpress/src/webdriver/ios_driver_extension.ts b/modules/@angular/benchpress/src/webdriver/ios_driver_extension.ts
index 5f55bc1111..effdd8b3b3 100644
--- a/modules/@angular/benchpress/src/webdriver/ios_driver_extension.ts
+++ b/modules/@angular/benchpress/src/webdriver/ios_driver_extension.ts
@@ -40,7 +40,7 @@ export class IOsDriverExtension extends WebDriverExtension {
         .then((_) => this._driver.logs('performance'))
         .then((entries) => {
           const records: any[] = [];
-          entries.forEach(entry => {
+          entries.forEach((entry: any) => {
             const message = JSON.parse(entry['message'])['message'];
             if (message['method'] === 'Timeline.eventRecorded') {
               records.push(message['params']['record']);
diff --git a/modules/@angular/compiler-cli/test/main_spec.ts b/modules/@angular/compiler-cli/test/main_spec.ts
index 370c9556ee..84f09a6379 100644
--- a/modules/@angular/compiler-cli/test/main_spec.ts
+++ b/modules/@angular/compiler-cli/test/main_spec.ts
@@ -154,7 +154,8 @@ describe('compiler-cli', () => {
           expect(mockConsole.error)
               .toHaveBeenCalledWith(
                   'Error at ' + path.join(basePath, 'test.ts') +
-                  ':3:7: Cannot invoke an expression whose type lacks a call signature.');
+                  ':3:7: Cannot invoke an expression whose type lacks a call signature. ' +
+                  'Type \'String\' has no compatible call signatures.');
           expect(mockConsole.error).not.toHaveBeenCalledWith('Compilation failed');
           expect(exitCode).toEqual(1);
           done();
diff --git a/modules/@angular/compiler/src/expression_parser/lexer.ts b/modules/@angular/compiler/src/expression_parser/lexer.ts
index 952aa37214..8f3cd60fc9 100644
--- a/modules/@angular/compiler/src/expression_parser/lexer.ts
+++ b/modules/@angular/compiler/src/expression_parser/lexer.ts
@@ -294,6 +294,8 @@ class _Scanner {
         buffer += input.substring(marker, this.index);
         this.advance();
         let unescapedCode: number;
+        // Workaround for TS2.1-introduced type strictness
+        this.peek = this.peek;
         if (this.peek == chars.$u) {
           // 4 character hex code for unicode character.
           const hex: string = input.substring(this.index + 1, this.index + 5);
diff --git a/modules/@angular/core/src/reflection/reflection_capabilities.ts b/modules/@angular/core/src/reflection/reflection_capabilities.ts
index c3dba802c6..e93652d315 100644
--- a/modules/@angular/core/src/reflection/reflection_capabilities.ts
+++ b/modules/@angular/core/src/reflection/reflection_capabilities.ts
@@ -16,7 +16,7 @@ import {GetterFn, MethodFn, SetterFn} from './types';
  * Attention: This regex has to hold even if the code is minified!
  */
 export const DELEGATE_CTOR =
-    /^function\s+\S+\(\)\s*{\s*("use strict";)?\s*(return\s+)?\S+\.apply\(this,\s*arguments\)/;
+    /^function\s+\S+\(\)\s*{\s*("use strict";)?\s*(return\s+)?(\S+\s+!==\s+null\s+&&\s+)?\S+\.apply\(this,\s*arguments\)/;
 
 export class ReflectionCapabilities implements PlatformReflectionCapabilities {
   private _reflect: any;
diff --git a/modules/@angular/examples/upgrade/static/ts/module.ts b/modules/@angular/examples/upgrade/static/ts/module.ts
index be70348d7e..0f6a83f831 100644
--- a/modules/@angular/examples/upgrade/static/ts/module.ts
+++ b/modules/@angular/examples/upgrade/static/ts/module.ts
@@ -115,6 +115,7 @@ class Ng2AppModule {
 // #docregion Angular 1 Stuff
 // #docregion ng1-module
 // This Angular 1 module represents the AngularJS pieces of the application
+declare var angular: ng.IAngularStatic;
 const ng1AppModule = angular.module('ng1AppModule', []);
 // #enddocregion
 
diff --git a/modules/@angular/language-service/src/ts_plugin.ts b/modules/@angular/language-service/src/ts_plugin.ts
index f24d5bd279..b4e6721f85 100644
--- a/modules/@angular/language-service/src/ts_plugin.ts
+++ b/modules/@angular/language-service/src/ts_plugin.ts
@@ -54,7 +54,12 @@ export function create(info: any /* ts.server.PluginCreateInfo */): ts.LanguageS
       const results = ls.getCompletionsAt(fileName, position);
       if (results && results.length) {
         if (base === undefined) {
-          base = {isMemberCompletion: false, isNewIdentifierLocation: false, entries: []};
+          base = {
+            isGlobalCompletion: false,
+            isMemberCompletion: false,
+            isNewIdentifierLocation: false,
+            entries: []
+          };
         }
         for (const entry of results) {
           base.entries.push(completionToEntry(entry));
@@ -78,7 +83,8 @@ export function create(info: any /* ts.server.PluginCreateInfo */): ts.LanguageS
           documentation: [],
           kind: 'angular',
           kindModifiers: 'what does this do?',
-          textSpan: {start: ours.span.start, length: ours.span.end - ours.span.start}
+          textSpan: {start: ours.span.start, length: ours.span.end - ours.span.start},
+          tags: [],
         };
       }
     });
diff --git a/modules/@angular/router/src/apply_redirects.ts b/modules/@angular/router/src/apply_redirects.ts
index 2b0aa4c452..779bebb3bd 100644
--- a/modules/@angular/router/src/apply_redirects.ts
+++ b/modules/@angular/router/src/apply_redirects.ts
@@ -20,7 +20,7 @@ import {EmptyError} from 'rxjs/util/EmptyError';
 
 import {Route, Routes} from './config';
 import {LoadedRouterConfig, RouterConfigLoader} from './router_config_loader';
-import {NavigationCancelingError, PRIMARY_OUTLET, Params, defaultUrlMatcher} from './shared';
+import {PRIMARY_OUTLET, Params, defaultUrlMatcher, navigationCancelingError} from './shared';
 import {UrlSegment, UrlSegmentGroup, UrlSerializer, UrlTree} from './url_tree';
 import {andObservables, forEach, merge, waitForMap, wrapIntoObservable} from './utils/collection';
 
@@ -50,7 +50,7 @@ function namedOutletsRedirect(redirectTo: string): Observable<any> {
 
 function canLoadFails(route: Route): Observable<LoadedRouterConfig> {
   return new Observable<LoadedRouterConfig>(
-      (obs: Observer<LoadedRouterConfig>) => obs.error(new NavigationCancelingError(
+      (obs: Observer<LoadedRouterConfig>) => obs.error(navigationCancelingError(
           `Cannot load children because the guard of the route "path: '${route.path}'" returned false`)));
 }
 
diff --git a/modules/@angular/router/src/router.ts b/modules/@angular/router/src/router.ts
index 7c9cc789f6..a54175bd74 100644
--- a/modules/@angular/router/src/router.ts
+++ b/modules/@angular/router/src/router.ts
@@ -31,7 +31,7 @@ import {DetachedRouteHandle, DetachedRouteHandleInternal, RouteReuseStrategy} fr
 import {LoadedRouterConfig, RouterConfigLoader} from './router_config_loader';
 import {RouterOutletMap} from './router_outlet_map';
 import {ActivatedRoute, ActivatedRouteSnapshot, RouterState, RouterStateSnapshot, advanceActivatedRoute, createEmptyState, equalParamsAndUrlSegments, inheritedParamsDataResolve} from './router_state';
-import {NavigationCancelingError, PRIMARY_OUTLET, Params} from './shared';
+import {PRIMARY_OUTLET, Params, isNavigationCancelingError} from './shared';
 import {DefaultUrlHandlingStrategy, UrlHandlingStrategy} from './url_handling_strategy';
 import {UrlSerializer, UrlTree, containsTree, createEmptyUrlTree} from './url_tree';
 import {andObservables, forEach, merge, waitForMap, wrapIntoObservable} from './utils/collection';
@@ -802,7 +802,7 @@ export class Router {
                 }
               },
               (e: any) => {
-                if (e instanceof NavigationCancelingError) {
+                if (isNavigationCancelingError(e)) {
                   this.resetUrlToCurrentUrlTree();
                   this.navigated = true;
                   this.routerEvents.next(
diff --git a/modules/@angular/router/src/shared.ts b/modules/@angular/router/src/shared.ts
index bd2798710e..e98940baca 100644
--- a/modules/@angular/router/src/shared.ts
+++ b/modules/@angular/router/src/shared.ts
@@ -27,13 +27,16 @@ export type Params = {
   [key: string]: any
 };
 
-export class NavigationCancelingError extends Error {
-  public stack: any;
-  constructor(public message: string) {
-    super(message);
-    this.stack = (<any>new Error(message)).stack;
-  }
-  toString(): string { return this.message; }
+const NAVIGATION_CANCELING_ERROR = 'ngNavigationCancelingError';
+
+export function navigationCancelingError(message: string) {
+  const error = Error('NavigationCancelingError: ' + message);
+  (error as any)[NAVIGATION_CANCELING_ERROR] = true;
+  return error;
+}
+
+export function isNavigationCancelingError(error: Error) {
+  return (error as any)[NAVIGATION_CANCELING_ERROR];
 }
 
 export function defaultUrlMatcher(
diff --git a/modules/@angular/router/test/apply_redirects.spec.ts b/modules/@angular/router/test/apply_redirects.spec.ts
index 87c60cef91..3e7afb8b38 100644
--- a/modules/@angular/router/test/apply_redirects.spec.ts
+++ b/modules/@angular/router/test/apply_redirects.spec.ts
@@ -214,7 +214,7 @@ describe('applyRedirects', () => {
               () => { throw 'Should not reach'; },
               (e) => {
                 expect(e.message).toEqual(
-                    `Cannot load children because the guard of the route "path: 'a'" returned false`);
+                    `NavigationCancelingError: Cannot load children because the guard of the route "path: 'a'" returned false`);
               });
     });
 
diff --git a/tools/@angular/tsc-wrapped/src/main.ts b/tools/@angular/tsc-wrapped/src/main.ts
index 325e6b30bf..54963a49e5 100644
--- a/tools/@angular/tsc-wrapped/src/main.ts
+++ b/tools/@angular/tsc-wrapped/src/main.ts
@@ -87,7 +87,7 @@ export function main(
       };
 
       const tsickleHost: tsickle.TsickleHost = {
-        shouldSkipTsickleProcessing: (fileName) => false,
+        shouldSkipTsickleProcessing: (fileName) => /\.d\.ts$/.test(fileName),
         pathToModuleName: (context, importPath) => '',
         shouldIgnoreWarningsForPath: (filePath) => false,
         fileNameToModuleId: (fileName) => fileName,
diff --git a/tools/@angular/tsc-wrapped/src/tsc.ts b/tools/@angular/tsc-wrapped/src/tsc.ts
index 9e606aa783..96889c9439 100644
--- a/tools/@angular/tsc-wrapped/src/tsc.ts
+++ b/tools/@angular/tsc-wrapped/src/tsc.ts
@@ -30,17 +30,27 @@ export class UserError extends Error {
   private _nativeError: Error;
 
   constructor(message: string) {
-    // Errors don't use current this, instead they create a new instance.
-    // We have to do forward all of our api to the nativeInstance.
-    const nativeError = super(message) as any as Error;
+    super(message);
+    // Required for TS 2.1, see
+    // https://github.com/Microsoft/TypeScript/wiki/Breaking-Changes#extending-built-ins-like-error-array-and-map-may-no-longer-work
+    Object.setPrototypeOf(this, UserError.prototype);
+
+    const nativeError = new Error(message) as any as Error;
     this._nativeError = nativeError;
   }
 
   get message() { return this._nativeError.message; }
-  set message(message) { this._nativeError.message = message; }
-  get name() { return 'UserError'; }
+  set message(message) {
+    if (this._nativeError) this._nativeError.message = message;
+  }
+  get name() { return this._nativeError.name; }
+  set name(name) {
+    if (this._nativeError) this._nativeError.name = name;
+  }
   get stack() { return (this._nativeError as any).stack; }
-  set stack(value) { (this._nativeError as any).stack = value; }
+  set stack(value) {
+    if (this._nativeError) (this._nativeError as any).stack = value;
+  }
   toString() { return this._nativeError.toString(); }
 }
 
@@ -133,7 +143,8 @@ export class Tsc implements CompilerInterface {
     const host = {
       useCaseSensitiveFileNames: true,
       fileExists: existsSync,
-      readDirectory: this.readDirectory
+      readDirectory: this.readDirectory,
+      readFile: ts.sys.readFile
     };
     this.parsed = ts.parseJsonConfigFileContent(config, host, basePath, existingOptions);
 
diff --git a/tools/@angular/tsc-wrapped/test/tsc.spec.ts b/tools/@angular/tsc-wrapped/test/tsc.spec.ts
index 8b694c46bd..68ca1e2d3d 100644
--- a/tools/@angular/tsc-wrapped/test/tsc.spec.ts
+++ b/tools/@angular/tsc-wrapped/test/tsc.spec.ts
@@ -7,7 +7,7 @@
  */
 
 import * as ts from 'typescript';
-import {Tsc, tsc as pureTsc} from '../src/tsc';
+import {Tsc} from '../src/tsc';
 import {VinylFile} from '../src/vinyl_file';
 
 describe('options parsing', () => {
@@ -41,7 +41,7 @@ describe('options parsing', () => {
   });
 
   it('should combine all options into ngOptions from vinyl like object', () => {
-    const {parsed, ngOptions} = pureTsc.readConfiguration(config as VinylFile, 'basePath');
+    const {parsed, ngOptions} = tsc.readConfiguration(config as VinylFile, 'basePath');
 
     expect(ngOptions).toEqual({
       genDir: 'basePath',
diff --git a/tools/@angular/tsc-wrapped/test/typescript.mocks.ts b/tools/@angular/tsc-wrapped/test/typescript.mocks.ts
index 94df009dfb..663fc1afbe 100644
--- a/tools/@angular/tsc-wrapped/test/typescript.mocks.ts
+++ b/tools/@angular/tsc-wrapped/test/typescript.mocks.ts
@@ -89,8 +89,8 @@ export class MockIdentifier extends MockNode implements ts.Identifier {
   public _expressionBrand: any;
 
   constructor(
-      public name: string, kind: ts.SyntaxKind = ts.SyntaxKind.Identifier, flags: ts.NodeFlags = 0,
-      pos: number = 0, end: number = 0) {
+      public name: string, public kind: ts.SyntaxKind.Identifier = ts.SyntaxKind.Identifier,
+      flags: ts.NodeFlags = 0, pos: number = 0, end: number = 0) {
     super(kind, flags, pos, end);
     this.text = name;
   }
@@ -100,7 +100,8 @@ export class MockVariableDeclaration extends MockNode implements ts.VariableDecl
   public _declarationBrand: any;
 
   constructor(
-      public name: ts.Identifier, kind: ts.SyntaxKind = ts.SyntaxKind.VariableDeclaration,
+      public name: ts.Identifier,
+      public kind: ts.SyntaxKind.VariableDeclaration = ts.SyntaxKind.VariableDeclaration,
       flags: ts.NodeFlags = 0, pos: number = 0, end: number = 0) {
     super(kind, flags, pos, end);
   }
@@ -119,6 +120,7 @@ export class MockSymbol implements ts.Symbol {
   getName(): string { return this.name; }
   getDeclarations(): ts.Declaration[] { return [this.node]; }
   getDocumentationComment(): ts.SymbolDisplayPart[] { return []; }
+  getJsDocTags(): ts.JSDocTagInfo[]{return []};
 
   static of (name: string): MockSymbol { return new MockSymbol(name); }
 }
diff --git a/tools/tslint/requireInternalWithUnderscoreRule.ts b/tools/tslint/requireInternalWithUnderscoreRule.ts
index e8afc10f3f..522edafae2 100644
--- a/tools/tslint/requireInternalWithUnderscoreRule.ts
+++ b/tools/tslint/requireInternalWithUnderscoreRule.ts
@@ -37,7 +37,7 @@ class TypedefWalker extends RuleWalker {
 
   private assertInternalAnnotationPresent(node: ts.Declaration) {
     if (node.name.getText().charAt(0) !== '_') return;
-    if (node.modifiers && node.modifiers.flags & ts.NodeFlags.Private) return;
+    if (ts.getCombinedModifierFlags(node) & ts.ModifierFlags.Private) return;
 
     const ranges = ts.getLeadingCommentRanges(this.getSourceFile().text, node.pos);
     if (ranges) {