diff --git a/hapi-fhir-docs/src/main/resources/ca/uhn/hapi/fhir/changelog/6_6_0/4734-subscription-regression.yaml b/hapi-fhir-docs/src/main/resources/ca/uhn/hapi/fhir/changelog/6_6_0/4734-subscription-regression.yaml
new file mode 100644
index 00000000000..3feca4ad054
--- /dev/null
+++ b/hapi-fhir-docs/src/main/resources/ca/uhn/hapi/fhir/changelog/6_6_0/4734-subscription-regression.yaml
@@ -0,0 +1,6 @@
+---
+type: fix
+issue: 4734
+title: "Fixed a regression introduced by 4624 that prevented subscriptions from loading into the in-memory
+subscription cache on system startup."
+
diff --git a/hapi-fhir-storage/src/main/java/ca/uhn/fhir/cache/BaseResourceCacheSynchronizer.java b/hapi-fhir-storage/src/main/java/ca/uhn/fhir/cache/BaseResourceCacheSynchronizer.java
index ee1d8d3da04..ebcb329c82e 100644
--- a/hapi-fhir-storage/src/main/java/ca/uhn/fhir/cache/BaseResourceCacheSynchronizer.java
+++ b/hapi-fhir-storage/src/main/java/ca/uhn/fhir/cache/BaseResourceCacheSynchronizer.java
@@ -64,9 +64,9 @@ public abstract class BaseResourceCacheSynchronizer implements IResourceChangeLi
 		mySearchParameterMap = getSearchParameterMap();
 		mySystemRequestDetails = SystemRequestDetails.forAllPartitions();
 
+		myEnabled = true;
 		IResourceChangeListenerCache resourceCache = myResourceChangeListenerRegistry.registerResourceResourceChangeListener(myResourceName, mySearchParameterMap, this, REFRESH_INTERVAL);
 		resourceCache.forceRefresh();
-		myEnabled = true;
 	}
 
 	@PreDestroy