diff --git a/packages/compiler-cli/src/ngtsc/imports/src/core.ts b/packages/compiler-cli/src/ngtsc/imports/src/core.ts
index 122b399829..eae858337b 100644
--- a/packages/compiler-cli/src/ngtsc/imports/src/core.ts
+++ b/packages/compiler-cli/src/ngtsc/imports/src/core.ts
@@ -65,6 +65,7 @@ const CORE_SUPPORTED_SYMBOLS = new Map<string, string>([
   ['ɵɵInjectorDef', 'ɵɵInjectorDef'],
   ['ɵɵNgModuleDefWithMeta', 'ɵɵNgModuleDefWithMeta'],
   ['ɵNgModuleFactory', 'NgModuleFactory'],
+  ['ɵnoSideEffects', 'ɵnoSideEffects'],
 ]);
 
 const CORE_MODULE = '@angular/core';
diff --git a/packages/compiler-cli/src/ngtsc/shims/src/factory_generator.ts b/packages/compiler-cli/src/ngtsc/shims/src/factory_generator.ts
index 8e54e282a5..08f633f056 100644
--- a/packages/compiler-cli/src/ngtsc/shims/src/factory_generator.ts
+++ b/packages/compiler-cli/src/ngtsc/shims/src/factory_generator.ts
@@ -63,7 +63,8 @@ export class FactoryGenerator implements PerFileShimGenerator, FactoryTracker {
       // because it won't miss any that do.
       const varLines = symbolNames.map(
           name => `export const ${
-              name}NgFactory: i0.ɵNgModuleFactory<any> = new i0.ɵNgModuleFactory(${name});`);
+              name}NgFactory: i0.ɵNgModuleFactory<any> = i0.ɵnoSideEffects(() => new i0.ɵNgModuleFactory(${
+              name}));`);
       sourceText += [
         // This might be incorrect if the current package being compiled is Angular core, but it's
         // okay to leave in at type checking time. TypeScript can handle this reference via its path
diff --git a/packages/compiler-cli/test/ngtsc/fake_core/index.ts b/packages/compiler-cli/test/ngtsc/fake_core/index.ts
index 7aad1050cf..bcbb9b0261 100644
--- a/packages/compiler-cli/test/ngtsc/fake_core/index.ts
+++ b/packages/compiler-cli/test/ngtsc/fake_core/index.ts
@@ -103,3 +103,5 @@ export interface QueryList<T>/* implements Iterable<T> */ {
 export type NgIterable<T> = Array<T>|Iterable<T>;
 
 export class NgZone {}
+
+export declare function ɵnoSideEffects<T>(fn: () => T): T;
diff --git a/packages/compiler-cli/test/ngtsc/ngtsc_spec.ts b/packages/compiler-cli/test/ngtsc/ngtsc_spec.ts
index 6e6848a80d..7af46bfd7c 100644
--- a/packages/compiler-cli/test/ngtsc/ngtsc_spec.ts
+++ b/packages/compiler-cli/test/ngtsc/ngtsc_spec.ts
@@ -3538,7 +3538,9 @@ runInEachFileSystem(os => {
       expect(factoryContents).toContain(`import * as i0 from '@angular/core';`);
       expect(factoryContents).toContain(`import { NotAModule, TestModule } from './test';`);
       expect(factoryContents)
-          .toContain(`export var TestModuleNgFactory = new i0.\u0275NgModuleFactory(TestModule);`);
+          .toContain(
+              'export var TestModuleNgFactory = ' +
+              'i0.ɵnoSideEffects(function () { return new i0.\u0275NgModuleFactory(TestModule); });');
       expect(factoryContents).not.toContain(`NotAModuleNgFactory`);
       expect(factoryContents).not.toContain('\u0275NonEmptyModule');
 
@@ -3677,11 +3679,14 @@ runInEachFileSystem(os => {
         env.driveMain();
 
         const factoryContents = env.getContents('test.ngfactory.js');
-        expect(normalize(factoryContents)).toBe(normalize(`
-        import * as i0 from "./r3_symbols";
-        import { TestModule } from './test';
-        export var TestModuleNgFactory = new i0.NgModuleFactory(TestModule);
-      `));
+        expect(normalize(factoryContents))
+            .toBe(
+                'import * as i0 from "./r3_symbols"; ' +
+                'import { TestModule } from \'./test\'; ' +
+                'export var TestModuleNgFactory = ' +
+                'i0.\u0275noSideEffects(function () { ' +
+                'return new i0.NgModuleFactory(TestModule); ' +
+                '});');
       });
 
       describe('file-level comments', () => {
diff --git a/packages/core/src/core_render3_private_export.ts b/packages/core/src/core_render3_private_export.ts
index d20a6449ac..01f844c351 100644
--- a/packages/core/src/core_render3_private_export.ts
+++ b/packages/core/src/core_render3_private_export.ts
@@ -292,5 +292,6 @@ export {
   ɵɵsanitizeUrl,
   ɵɵsanitizeUrlOrResourceUrl,
 } from './sanitization/sanitization';
+export {noSideEffects as ɵnoSideEffects} from './util/closure';
 
 // clang-format on
diff --git a/packages/core/src/r3_symbols.ts b/packages/core/src/r3_symbols.ts
index 391bb8bf56..1ee3762e83 100644
--- a/packages/core/src/r3_symbols.ts
+++ b/packages/core/src/r3_symbols.ts
@@ -28,6 +28,7 @@ export {ɵɵdefineNgModule} from './render3/definition';
 export {ɵɵFactoryDef} from './render3/interfaces/definition';
 export {setClassMetadata} from './render3/metadata';
 export {NgModuleFactory} from './render3/ng_module_ref';
+export {noSideEffects as ɵnoSideEffects} from './util/closure';