diff --git a/integration/ngcc/test.sh b/integration/ngcc/test.sh
index efa8901f7a..0e8e17d49e 100755
--- a/integration/ngcc/test.sh
+++ b/integration/ngcc/test.sh
@@ -39,6 +39,12 @@ ivy-ngcc
   grep "static ngInjectorDef: ɵngcc0.InjectorDef<ApplicationModule>;" node_modules/@angular/core/src/application_module.d.ts
   if [[ $? != 0 ]]; then exit 1; fi
 
+# Did it generate a base factory call for synthesized constructors correctly?
+  grep "const ɵMatTable_BaseFactory = ɵngcc0.ɵgetInheritedFactory(MatTable);" node_modules/@angular/material/esm2015/table.js
+  if [[ $? != 0 ]]; then exit 1; fi
+  grep "const ɵMatTable_BaseFactory = ɵngcc0.ɵgetInheritedFactory(MatTable);" node_modules/@angular/material/esm5/table.es5.js
+  if [[ $? != 0 ]]; then exit 1; fi
+
 # Can it be safely run again (as a noop)?
 ivy-ngcc
 
diff --git a/packages/compiler-cli/src/ngcc/src/host/esm2015_host.ts b/packages/compiler-cli/src/ngcc/src/host/esm2015_host.ts
index c3e57f23bf..e4241d62d9 100644
--- a/packages/compiler-cli/src/ngcc/src/host/esm2015_host.ts
+++ b/packages/compiler-cli/src/ngcc/src/host/esm2015_host.ts
@@ -800,10 +800,16 @@ export class Esm2015ReflectionHost extends TypeScriptReflectionHost implements N
     if (constructorSymbol) {
       // For some reason the constructor does not have a `valueDeclaration` ?!?
       const constructor = constructorSymbol.declarations &&
-          constructorSymbol.declarations[0] as ts.ConstructorDeclaration;
-      if (constructor && constructor.parameters) {
+          constructorSymbol.declarations[0] as ts.ConstructorDeclaration | undefined;
+      if (!constructor) {
+        return [];
+      }
+      if (constructor.parameters.length > 0) {
         return Array.from(constructor.parameters);
       }
+      if (isSynthesizedConstructor(constructor)) {
+        return null;
+      }
       return [];
     }
     return null;
@@ -1228,3 +1234,52 @@ function collectExportedDeclarations(
     });
   }
 }
+
+
+/**
+ * A constructor function may have been "synthesized" by TypeScript during JavaScript emit,
+ * in the case no user-defined constructor exists and e.g. property initializers are used.
+ * Those initializers need to be emitted into a constructor in JavaScript, so the TypeScript
+ * compiler generates a synthetic constructor.
+ *
+ * We need to identify such constructors as ngcc needs to be able to tell if a class did
+ * originally have a constructor in the TypeScript source. When a class has a superclass,
+ * a synthesized constructor must not be considered as a user-defined constructor as that
+ * prevents a base factory call from being created by ngtsc, resulting in a factory function
+ * that does not inject the dependencies of the superclass. Hence, we identify a default
+ * synthesized super call in the constructor body, according to the structure that TypeScript
+ * emits during JavaScript emit:
+ * https://github.com/Microsoft/TypeScript/blob/v3.2.2/src/compiler/transformers/ts.ts#L1068-L1082
+ *
+ * @param constructor a constructor function to test
+ * @returns true if the constructor appears to have been synthesized
+ */
+function isSynthesizedConstructor(constructor: ts.ConstructorDeclaration): boolean {
+  if (!constructor.body) return false;
+
+  const firstStatement = constructor.body.statements[0];
+  if (!firstStatement || !ts.isExpressionStatement(firstStatement)) return false;
+
+  return isSynthesizedSuperCall(firstStatement.expression);
+}
+
+/**
+ * Tests whether the expression appears to have been synthesized by TypeScript, i.e. whether
+ * it is of the following form:
+ *
+ * ```
+ * super(...arguments);
+ * ```
+ *
+ * @param expression the expression that is to be tested
+ * @returns true if the expression appears to be a synthesized super call
+ */
+function isSynthesizedSuperCall(expression: ts.Expression): boolean {
+  if (!ts.isCallExpression(expression)) return false;
+  if (expression.expression.kind !== ts.SyntaxKind.SuperKeyword) return false;
+  if (expression.arguments.length !== 1) return false;
+
+  const argument = expression.arguments[0];
+  return ts.isSpreadElement(argument) && ts.isIdentifier(argument.expression) &&
+      argument.expression.text === 'arguments';
+}
diff --git a/packages/compiler-cli/src/ngcc/src/host/esm5_host.ts b/packages/compiler-cli/src/ngcc/src/host/esm5_host.ts
index 9482e7730e..db04510eaa 100644
--- a/packages/compiler-cli/src/ngcc/src/host/esm5_host.ts
+++ b/packages/compiler-cli/src/ngcc/src/host/esm5_host.ts
@@ -41,6 +41,24 @@ export class Esm5ReflectionHost extends Esm2015ReflectionHost {
     return super.isClass(node) || !!this.getClassSymbol(node);
   }
 
+  /**
+   * Determines whether the given declaration has a base class.
+   *
+   * In ES5, we need to determine if the IIFE wrapper takes a `_super` parameter .
+   */
+  hasBaseClass(node: ts.Declaration): boolean {
+    const classSymbol = this.getClassSymbol(node);
+    if (!classSymbol) return false;
+
+    const iifeBody = classSymbol.valueDeclaration.parent;
+    if (!iifeBody || !ts.isBlock(iifeBody)) return false;
+
+    const iife = iifeBody.parent;
+    if (!iife || !ts.isFunctionExpression(iife)) return false;
+
+    return iife.parameters.length === 1 && isSuperIdentifier(iife.parameters[0].name);
+  }
+
   /**
    * Find a symbol for a node that we think is a class.
    *
@@ -137,11 +155,15 @@ export class Esm5ReflectionHost extends Esm2015ReflectionHost {
    * @returns an array of `ts.ParameterDeclaration` objects representing each of the parameters in
    * the class's constructor or null if there is no constructor.
    */
-  protected getConstructorParameterDeclarations(classSymbol: ts.Symbol): ts.ParameterDeclaration[] {
+  protected getConstructorParameterDeclarations(classSymbol: ts.Symbol):
+      ts.ParameterDeclaration[]|null {
     const constructor = classSymbol.valueDeclaration as ts.FunctionDeclaration;
-    if (constructor && constructor.parameters) {
+    if (constructor.parameters.length > 0) {
       return Array.from(constructor.parameters);
     }
+    if (isSynthesizedConstructor(constructor)) {
+      return null;
+    }
     return [];
   }
 
@@ -253,6 +275,147 @@ function reflectArrayElement(element: ts.Expression) {
   return ts.isObjectLiteralExpression(element) ? reflectObjectLiteral(element) : null;
 }
 
+/**
+ * A constructor function may have been "synthesized" by TypeScript during JavaScript emit,
+ * in the case no user-defined constructor exists and e.g. property initializers are used.
+ * Those initializers need to be emitted into a constructor in JavaScript, so the TypeScript
+ * compiler generates a synthetic constructor.
+ *
+ * We need to identify such constructors as ngcc needs to be able to tell if a class did
+ * originally have a constructor in the TypeScript source. For ES5, we can not tell an
+ * empty constructor apart from a synthesized constructor, but fortunately that does not
+ * matter for the code generated by ngtsc.
+ *
+ * When a class has a superclass however, a synthesized constructor must not be considered
+ * as a user-defined constructor as that prevents a base factory call from being created by
+ * ngtsc, resulting in a factory function that does not inject the dependencies of the
+ * superclass. Hence, we identify a default synthesized super call in the constructor body,
+ * according to the structure that TypeScript's ES2015 to ES5 transformer generates in
+ * https://github.com/Microsoft/TypeScript/blob/v3.2.2/src/compiler/transformers/es2015.ts#L1082-L1098
+ *
+ * @param constructor a constructor function to test
+ * @returns true if the constructor appears to have been synthesized
+ */
+function isSynthesizedConstructor(constructor: ts.FunctionDeclaration): boolean {
+  if (!constructor.body) return false;
+
+  const firstStatement = constructor.body.statements[0];
+  if (!firstStatement) return false;
+
+  return isSynthesizedSuperThisAssignment(firstStatement) ||
+      isSynthesizedSuperReturnStatement(firstStatement);
+}
+
+/**
+ * Identifies a synthesized super call of the form:
+ *
+ * ```
+ * var _this = _super !== null && _super.apply(this, arguments) || this;
+ * ```
+ *
+ * @param statement a statement that may be a synthesized super call
+ * @returns true if the statement looks like a synthesized super call
+ */
+function isSynthesizedSuperThisAssignment(statement: ts.Statement): boolean {
+  if (!ts.isVariableStatement(statement)) return false;
+
+  const variableDeclarations = statement.declarationList.declarations;
+  if (variableDeclarations.length !== 1) return false;
+
+  const variableDeclaration = variableDeclarations[0];
+  if (!ts.isIdentifier(variableDeclaration.name) ||
+      !variableDeclaration.name.text.startsWith('_this'))
+    return false;
+
+  const initializer = variableDeclaration.initializer;
+  if (!initializer) return false;
+
+  return isSynthesizedDefaultSuperCall(initializer);
+}
+/**
+ * Identifies a synthesized super call of the form:
+ *
+ * ```
+ * return _super !== null && _super.apply(this, arguments) || this;
+ * ```
+ *
+ * @param statement a statement that may be a synthesized super call
+ * @returns true if the statement looks like a synthesized super call
+ */
+function isSynthesizedSuperReturnStatement(statement: ts.Statement): boolean {
+  if (!ts.isReturnStatement(statement)) return false;
+
+  const expression = statement.expression;
+  if (!expression) return false;
+
+  return isSynthesizedDefaultSuperCall(expression);
+}
+
+/**
+ * Tests whether the expression is of the form:
+ *
+ * ```
+ * _super !== null && _super.apply(this, arguments) || this;
+ * ```
+ *
+ * This structure is generated by TypeScript when transforming ES2015 to ES5, see
+ * https://github.com/Microsoft/TypeScript/blob/v3.2.2/src/compiler/transformers/es2015.ts#L1148-L1163
+ *
+ * @param expression an expression that may represent a default super call
+ * @returns true if the expression corresponds with the above form
+ */
+function isSynthesizedDefaultSuperCall(expression: ts.Expression): boolean {
+  if (!isBinaryExpr(expression, ts.SyntaxKind.BarBarToken)) return false;
+  if (expression.right.kind !== ts.SyntaxKind.ThisKeyword) return false;
+
+  const left = expression.left;
+  if (!isBinaryExpr(left, ts.SyntaxKind.AmpersandAmpersandToken)) return false;
+
+  return isSuperNotNull(left.left) && isSuperApplyCall(left.right);
+}
+
+function isSuperNotNull(expression: ts.Expression): boolean {
+  return isBinaryExpr(expression, ts.SyntaxKind.ExclamationEqualsEqualsToken) &&
+      isSuperIdentifier(expression.left);
+}
+
+/**
+ * Tests whether the expression is of the form
+ *
+ * ```
+ * _super.apply(this, arguments)
+ * ```
+ *
+ * @param expression an expression that may represent a default super call
+ * @returns true if the expression corresponds with the above form
+ */
+function isSuperApplyCall(expression: ts.Expression): boolean {
+  if (!ts.isCallExpression(expression) || expression.arguments.length !== 2) return false;
+
+  const targetFn = expression.expression;
+  if (!ts.isPropertyAccessExpression(targetFn)) return false;
+  if (!isSuperIdentifier(targetFn.expression)) return false;
+  if (targetFn.name.text !== 'apply') return false;
+
+  const thisArgument = expression.arguments[0];
+  if (thisArgument.kind !== ts.SyntaxKind.ThisKeyword) return false;
+
+  const argumentsArgument = expression.arguments[1];
+  return ts.isIdentifier(argumentsArgument) && argumentsArgument.text === 'arguments';
+}
+
+function isBinaryExpr(
+    expression: ts.Expression, operator: ts.BinaryOperator): expression is ts.BinaryExpression {
+  return ts.isBinaryExpression(expression) && expression.operatorToken.kind === operator;
+}
+
+function isSuperIdentifier(node: ts.Node): boolean {
+  // Verify that the identifier is prefixed with `_super`. We don't test for equivalence
+  // as TypeScript may have suffixed the name, e.g. `_super_1` to avoid name conflicts.
+  // Requiring only a prefix should be sufficiently accurate.
+  return ts.isIdentifier(node) && node.text.startsWith('_super');
+}
+
 /**
  * Parse the statement to extract the ESM5 parameter initializer if there is one.
  * If one is found, add it to the appropriate parameter in the `parameters` collection.
diff --git a/packages/compiler-cli/src/ngcc/test/host/esm2015_host_spec.ts b/packages/compiler-cli/src/ngcc/test/host/esm2015_host_spec.ts
index a68191af74..9248f76586 100644
--- a/packages/compiler-cli/src/ngcc/test/host/esm2015_host_spec.ts
+++ b/packages/compiler-cli/src/ngcc/test/host/esm2015_host_spec.ts
@@ -980,6 +980,70 @@ describe('Fesm2015ReflectionHost', () => {
       }));
     });
 
+    describe('synthesized constructors', () => {
+      function getConstructorParameters(constructor: string) {
+        const file = {
+          name: '/synthesized_constructors.js',
+          contents: `
+            class BaseClass {}
+            class TestClass extends BaseClass {
+              ${constructor}
+            }
+          `,
+        };
+
+        const program = makeTestProgram(file);
+        const host = new Esm2015ReflectionHost(false, program.getTypeChecker());
+        const classNode = getDeclaration(program, file.name, 'TestClass', ts.isClassDeclaration);
+        return host.getConstructorParameters(classNode);
+      }
+
+      it('recognizes super call as first statement', () => {
+        const parameters = getConstructorParameters(`
+          constructor() {
+            super(...arguments);
+            this.synthesizedProperty = null;
+          }`);
+
+        expect(parameters).toBeNull();
+      });
+
+      it('does not consider super call without spread element as synthesized', () => {
+        const parameters = getConstructorParameters(`
+          constructor() {
+            super(arguments);
+          }`);
+
+        expect(parameters !.length).toBe(0);
+      });
+
+      it('does not consider constructors with parameters as synthesized', () => {
+        const parameters = getConstructorParameters(`
+          constructor(arg) {
+            super(...arguments);
+          }`);
+
+        expect(parameters !.length).toBe(1);
+      });
+
+      it('does not consider manual super calls as synthesized', () => {
+        const parameters = getConstructorParameters(`
+          constructor() {
+            super();
+          }`);
+
+        expect(parameters !.length).toBe(0);
+      });
+
+      it('does not consider empty constructors as synthesized', () => {
+        const parameters = getConstructorParameters(`
+          constructor() {
+          }`);
+
+        expect(parameters !.length).toBe(0);
+      });
+    });
+
     describe('(returned parameters `decorators`)', () => {
       it('should ignore param decorator elements that are not object literals', () => {
         const program = makeTestProgram(INVALID_CTOR_DECORATORS_FILE);
diff --git a/packages/compiler-cli/src/ngcc/test/host/esm5_host_spec.ts b/packages/compiler-cli/src/ngcc/test/host/esm5_host_spec.ts
index 7889ae74d3..1501869fc9 100644
--- a/packages/compiler-cli/src/ngcc/test/host/esm5_host_spec.ts
+++ b/packages/compiler-cli/src/ngcc/test/host/esm5_host_spec.ts
@@ -946,6 +946,84 @@ describe('Esm5ReflectionHost', () => {
       });
     });
 
+    describe('synthesized constructors', () => {
+      function getConstructorParameters(constructor: string) {
+        const file = {
+          name: '/synthesized_constructors.js',
+          contents: `
+            var TestClass = /** @class */ (function (_super) {
+              __extends(TestClass, _super);
+              ${constructor}
+              return TestClass;
+            }(null));
+          `,
+        };
+
+        const program = makeTestProgram(file);
+        const host = new Esm5ReflectionHost(false, program.getTypeChecker());
+        const classNode = getDeclaration(program, file.name, 'TestClass', ts.isVariableDeclaration);
+        return host.getConstructorParameters(classNode);
+      }
+
+      it('recognizes _this assignment from super call', () => {
+        const parameters = getConstructorParameters(`
+          function TestClass() {
+            var _this = _super !== null && _super.apply(this, arguments) || this;
+            _this.synthesizedProperty = null;
+            return _this;
+          }`);
+
+        expect(parameters).toBeNull();
+      });
+
+      it('recognizes super call as return statement', () => {
+        const parameters = getConstructorParameters(`
+          function TestClass() {
+            return _super !== null && _super.apply(this, arguments) || this;
+          }`);
+
+        expect(parameters).toBeNull();
+      });
+
+      it('handles the case where a unique name was generated for _super or _this', () => {
+        const parameters = getConstructorParameters(`
+          function TestClass() {
+            var _this_1 = _super_1 !== null && _super_1.apply(this, arguments) || this;
+            _this_1._this = null;
+            _this_1._super = null;
+            return _this_1;
+          }`);
+
+        expect(parameters).toBeNull();
+      });
+
+      it('does not consider constructors with parameters as synthesized', () => {
+        const parameters = getConstructorParameters(`
+          function TestClass(arg) {
+            return _super !== null && _super.apply(this, arguments) || this;
+          }`);
+
+        expect(parameters !.length).toBe(1);
+      });
+
+      it('does not consider manual super calls as synthesized', () => {
+        const parameters = getConstructorParameters(`
+          function TestClass() {
+            return _super.call(this) || this;
+          }`);
+
+        expect(parameters !.length).toBe(0);
+      });
+
+      it('does not consider empty constructors as synthesized', () => {
+        const parameters = getConstructorParameters(`
+          function TestClass() {
+          }`);
+
+        expect(parameters !.length).toBe(0);
+      });
+    });
+
     describe('(returned parameters `decorators.args`)', () => {
       it('should be an empty array if param decorator has no `args` property', () => {
         const program = makeTestProgram(INVALID_CTOR_DECORATOR_ARGS_FILE);
@@ -1252,6 +1330,51 @@ describe('Esm5ReflectionHost', () => {
     });
   });
 
+  describe('hasBaseClass()', () => {
+    function hasBaseClass(source: string) {
+      const file = {
+        name: '/synthesized_constructors.js',
+        contents: source,
+      };
+
+      const program = makeTestProgram(file);
+      const host = new Esm5ReflectionHost(false, program.getTypeChecker());
+      const classNode = getDeclaration(program, file.name, 'TestClass', ts.isVariableDeclaration);
+      return host.hasBaseClass(classNode);
+    }
+
+    it('should consider an IIFE with _super parameter as having a base class', () => {
+      const result = hasBaseClass(`
+        var TestClass = /** @class */ (function (_super) {
+          __extends(TestClass, _super);
+          function TestClass() {}
+          return TestClass;
+        }(null));`);
+      expect(result).toBe(true);
+    });
+
+    it('should consider an IIFE with a unique name generated for the _super parameter as having a base class',
+       () => {
+         const result = hasBaseClass(`
+        var TestClass = /** @class */ (function (_super_1) {
+          __extends(TestClass, _super_1);
+          function TestClass() {}
+          return TestClass;
+        }(null));`);
+         expect(result).toBe(true);
+       });
+
+    it('should not consider an IIFE without parameter as having a base class', () => {
+      const result = hasBaseClass(`
+        var TestClass = /** @class */ (function () {
+          __extends(TestClass, _super);
+          function TestClass() {}
+          return TestClass;
+        }(null));`);
+      expect(result).toBe(false);
+    });
+  });
+
   describe('findDecoratedClasses()', () => {
     it('should return an array of all decorated classes in the given source file', () => {
       const program = makeTestProgram(...DECORATED_FILES);
diff --git a/packages/compiler-cli/src/ngtsc/reflection/src/host.ts b/packages/compiler-cli/src/ngtsc/reflection/src/host.ts
index c82cadd190..c8b5512694 100644
--- a/packages/compiler-cli/src/ngtsc/reflection/src/host.ts
+++ b/packages/compiler-cli/src/ngtsc/reflection/src/host.ts
@@ -425,6 +425,9 @@ export interface ReflectionHost {
    */
   isClass(node: ts.Node): node is ts.NamedDeclaration;
 
+  /**
+   * Determines whether the given declaration has a base class.
+   */
   hasBaseClass(node: ts.Declaration): boolean;
 
   /**